Recent methodological advances admit optical imaging of subcellular structures with resolution that is below the diffraction limit. In a typical application, fluorescent labels are chemically attached to the structure to be imaged at very high density, often disrupting the process to be studied or even killing the cell. In collaboration with the Arce group in electrical engineering at UD, we are using new ideas from signal processing to reconstruct super resolved images from far less data, with an eye to reducing labeling densities and reducing acquisition times.